I am a heavy Minecraft mod player, and Botania is one I return to often. It has a very unusual mana-producing flower called the Dandelifeon.
This flower runs a 25*25 Conway's Game of Life, then uses the mod's rules to decide how much mana it produces. Of course, more is better.
So I tried pure random search, simulated annealing, and a genetic algorithm to find game setups that produce the most mana. Pretty cool.